Sec Form 3 Filing - Delaet Ingrid @ NEUROCRINE BIOSCIENCES INC - 2023-02-09

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Delaet Ingrid 2. Issuer Name and Ticker or Trading Symbol NEUROCRINE BIOSCIENCES INC [ NBIX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Regulatory Officer (Last) (First) (Middle) 12780 EL CAMINO REAL 3. Date of Earliest Transaction (MM/DD/YY) 02/09/2023 (Street) SAN DIEGO, CA92130 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 3,382 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Incentive Stock Option $ 106.02 ( 1 ) 02/01/2031 Common Stock 3,359 D Non-Qualified Stock Option $ 106.02 ( 1 ) 02/01/2031 Common Stock 9,367 D Incentive Stock Option $ 79.02 ( 2 ) 01/31/2032 Common Stock 827 D Non-Qualified Stock Option $ 79.02 ( 2 ) 01/31/2032 Common Stock 12,261 D Restricted Stock Unit ( 4 ) ( 3 ) ( 3 ) Common Stock 4,717 D Restricted Stock Unit ( 4 ) ( 5 ) ( 5 ) Common Stock 5,435 D Restriced Stock Unit ( 4 ) ( 6 ) ( 6 ) Common Stock 3,202 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Delaet Ingrid 12780 EL CAMINO REAL SAN DIEGO, CA92130 Chief Regulatory Officer Signatures /s/ Darin Lippoldt, Attorney-in-Fact 02/15/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Option granted February 1, 2021 and vests at 25% upon first anniversary (February 1, 2022) and remaining 75% vesting in 36 equal monthly installments beginning on March 1, 2022. ( 2 )Option granted January 31, 2022 and vests monthly over four years. ( 3 )1/4 of the Restricted Stock Units vested on February 1, 2022 and February 1, 2023.The remaining units vest equally on each of February 1, 2024 and February 1, 2025. ( 4 )Each Restricted Stock Unit represents a contingent right to receive one share of the Issuer Common Stock. ( 5 )1/2 of the Restricted Stock Units vested on August 27, 2022. The remaining units will vest on August 27, 2023. ( 6 )1/4 of the Restricted Stock Units vested on January 31, 2023. The remaining units vest equally on each of January 31, 2024, January 31, 2025, January 26, 2026.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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