Sec Form 4 Filing - BVF PARTNERS L P/IL @ CTI BIOPHARMA CORP - 2022-03-09

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person BVF PARTNERS L P/IL 2. Issuer Name and Ticker or Trading Symbol CTI BIOPHARMA CORP [ CTIC] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director X __ 10% Owner _____ Officer (give title below) X __ Other (specify below) See Remarks (Last) (First) (Middle) 44 MONTGOMERY ST., 40TH FL 3. Date of Earliest Transaction (MM/DD/YY) 03/09/2022 (Street) SAN FRANCISCO, CA94104 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock, par value $0.001( 1 ) 4,085,933 D( 2 ) Common Stock, par value $0.001( 1 ) 3,059,296 D( 3 ) Common Stock, par value $0.001( 1 ) 488,879 D( 4 ) Common Stock, par value $0.001( 1 ) 1,295,582 I( 5 ) See footnote( 5 ) Common Stock, par value $0.001( 1 ) 43,139 I( 10 ) See footnote( 10 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Series X Convertible Preferred Stock( 1 )( 8 ) $ 10,000 ( 6 ) ( 6 ) Common Stock, par value $0.001 15,940,000 1,594 D( 2 ) Series X Convertible Preferred Stock( 1 )( 8 ) $ 10,000 ( 6 ) ( 6 ) Common Stock, par value $0.001 12,500,000 1,250 D( 3 ) Series X Convertible Preferred Stock( 1 )( 8 ) $ 10,000 ( 6 ) ( 6 ) Common Stock, par value $0.001 1,910,000 191 D( 4 ) Series X Convertible Preferred Stock( 1 )( 8 ) $ 10,000 ( 6 ) ( 6 ) Common Stock, par value $0.001 120,000 12 I( 5 ) See footnote( 5 ) Series O Convertible Preferred Stock( 1 ) $ 2,001 ( 7 ) ( 7 ) Common Stock, par value $0.001 3,754,000 5,631 D( 2 ) Series O Convertible Preferred Stock( 1 ) $ 2,001 ( 7 ) ( 7 ) Common Stock, par value $0.001 2,426,667 3,640 D( 3 ) Series O Convertible Preferred Stock( 1 ) $ 2,001 ( 7 ) ( 7 ) Common Stock, par value $0.001 682,666 1,024 D( 4 ) Series O Convertible Preferred Stock( 1 ) $ 2,001 ( 7 ) ( 7 ) Common Stock, par value $0.001 1,520,000 2,280 I( 5 ) See footnote( 5 ) Non-Qualified Stock Option (Right to Buy)( 10 ) $ 0.8411 ( 11 ) 05/16/2029 Common Stock, par value $0.001 120,000 120,000 I( 10 ) See footnote( 10 ) Non-Qualified Stock Option (Right to Buy)( 10 ) $ 4.61 ( 12 ) 05/17/2028 Common Stock, par value $0.001 60,000 60,000 I( 10 ) See footnote( 10 ) Stock Option (Right to Buy)( 10 ) $ 4.25 ( 13 ) 02/22/2027 Common Stock, par value $0.001 50,000 50,000 I( 10 ) See footnote( 10 ) Stock Option (Right to Buy)( 10 ) $ 3.3 ( 9 ) 03/10/2031 Common Stock, par value $0.001 80,000 80,000 I( 10 ) See footnote( 10 ) Series X1 Convertible Preferred Stock( 1 ) ( 14 ) ( 14 ) ( 14 ) Common Stock, par value $0.001 3,440,000 344 D( 2 ) Series X1 Convertible Preferred Stock( 1 ) ( 14 ) ( 14 ) ( 14 ) Common Stock, par value $0.001 2,390,000 239 D( 3 ) Series X1 Convertible Preferred Stock( 1 ) ( 14 ) ( 14 ) ( 14 ) Common Stock, par value $0.001 170,000 17 D( 4 ) Stock Option (Right to Buy)( 10 ) $ 4.49 03/09/2022 A 80,000 ( 15 ) 03/09/2032 Common Stock, par value $0.001 80,000 $ 0 80,000 I( 10 ) See footnote( 10 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other BVF PARTNERS L P/IL 44 MONTGOMERY ST. 40TH FL SAN FRANCISCO, CA94104 X X See Remarks BIOTECHNOLOGY VALUE FUND L P 44 MONTGOMERY ST. 40TH FL SAN FRANCISCO, CA94104 X See Explanation of Responses BVF I GP LLC 44 MONTGOMERY ST., 40TH FLOOR SAN FRANCISCO, CA94104 X See Explanation of Responses BIOTECHNOLOGY VALUE FUND II LP 44 MONTGOMERY ST. 40TH FL SAN FRANCISCO, CA94104 See Explanation of Responses BVF II GP LLC 44 MONTGOMERY ST., 40TH FLOOR SAN FRANCISCO, CA94104 See Explanation of Responses Biotechnology Value Trading Fund OS LP P.O. BOX 309 UGLAND HOUSE GRAND CAYMAN, E9KY1-1104 See Explanation of Responses BVF Partners OS Ltd. P.O. BOX 309 UGLAND HOUSE GRAND CAYMAN, E9KY1-1104 See Explanation of Responses BVF GP HOLDINGS LLC 44 MONTGOMERY ST., 40TH FLOOR SAN FRANCISCO, CA94104 X See Explanation of Responses BVF INC/IL 44 MONTGOMERY ST. 40TH FL SAN FRANCISCO, CA94104 X See Explanation of Responses LAMPERT MARK N 44 MONTGOMERY ST. 40TH FL SAN FRANCISCO, CA94104 X See Explanation of Responses Signatures BVF Partners L.P., By: BVF Inc., its general partner, By: /s/ Mark N. Lampert, President 03/11/2022 Signature of Reporting Person Date Biotechnology Value Fund, L.P., By: BVF I GP LLC, its general partner, By: /s/ Mark N. Lampert, Chief Executive Officer 03/11/2022 Signature of Reporting Person Date BVF I GP LLC, By: /s/ Mark N. Lampert, Chief Executive Officer 03/11/2022 Signature of Reporting Person Date Biotechnology Value Fund II, L.P., By: BVF II GP LLC, its general partner, By: /s/ Mark N. Lampert, Chief Executive Officer 03/11/2022 Signature of Reporting Person Date BVF II GP LLC, By: /s/ Mark N. Lampert, Chief Executive Officer 03/11/2022 Signature of Reporting Person Date BVF Partners OS Ltd., By: BVF Partners L.P., its sole member, By: BVF Inc., its general partner, By: /s/ Mark N. Lampert, President 03/11/2022 Signature of Reporting Person Date Biotechnology Value Trading Fund OS LP, By: BVF Partners L.P., its investment manager, BVF Inc., its general partner, By: /s/ Mark N. Lampert, President 03/11/2022 Signature of Reporting Person Date BVF GP Holdings LLC, By: /s/ Mark N. Lampert, Chief Executive Officer 03/11/2022 Signature of Reporting Person Date BVF Inc., By: /s/ Mark N. Lampert, President 03/11/2022 Signature of Reporting Person Date /s/ Mark N. Lampert 03/11/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )This Form 4 is filed jointly by Biotechnology Value Fund, L.P. ("BVF"), Biotechnology Value Fund II, L.P. ("BVF2"), Biotechnology Value Trading Fund OS LP ("Trading Fund OS"), BVF Partners OS Ltd. ("Partners OS"), BVF I GP LLC ("BVF GP"), BVF II GP LLC ("BVF2 GP"), BVF GP Holdings LLC ("BVF GPH"), BVF Partners L.P. ("Partners"), BVF Inc. and Mark N. Lampert (collectively, the "Reporting Persons"). Each of the Reporting Persons is a member of a Section 13(d) group that collectively owns more than 10% of the Issuer's outstanding shares of Common Stock, par value $0.001 (the "Common Stock"). Each of the Reporting Persons disclaims beneficial ownership of the securities reported herein except to the extent of his or its pecuniary interest therein. ( 2 )Securities owned directly by BVF. As the general partner of BVF, BVF GP may be deemed to beneficially own the securities owned directly by BVF. As the sole member of BVF GP, BVF GPH may be deemed to beneficially own securities owned directly by BVF. As the investment manager of BVF, Partners may be deemed to beneficially own the securities owned directly by BVF. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF. ( 3 )Securities owned directly by BVF2. As the general partner of BVF2, BVF2 GP may be deemed to beneficially own the securities owned directly by BVF2. As the sole member of BVF2 GP, BVF GPH may be deemed to beneficially own securities owned directly by BVF2. As the investment manager of BVF2, Partners may be deemed to beneficially own the securities owned directly by BVF2. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by BVF2. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by BVF2. ( 4 )Securities owned directly by Trading Fund OS. As the general partner of Trading Fund OS, Partners OS may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment manager of Trading Fund OS and the sole member of Partners OS, Partners may be deemed to beneficially own the securities owned directly by Trading Fund OS. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities owned directly by Trading Fund OS. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities owned directly by Trading Fund OS. ( 5 )Securities held in certain Partners managed accounts (the "Partners Managed Accounts"). Partners, as the investment manager of the Partners Managed Accounts, may be deemed to beneficially own the securities held by the Partners Managed Accounts. As the investment adviser and general partner of Partners, BVF Inc. may be deemed to beneficially own the securities held by the Partners Managed Accounts. As a director and officer of BVF Inc., Mr. Lampert may be deemed to beneficially own the securities held by the Partners Managed Accounts. ( 6 )The Series X Convertible Preferred Stock, par value $0.001 per share (the "Series X Preferred Stock") are convertible into shares of Common Stock at any time at the option of the holder thereof. Each share of Series X Preferred Stock is convertible into 10,000 shares of Common Stock. The Series X Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 9.99% of the shares of Common Stock outstanding immediately after giving effect to such conversion. ( 7 )The Series O Convertible Preferred Stock, par value $0.001 per share (the "Series O Preferred Stock") have no expiration date, and are convertible upon issuance; the conversion ratio is 667 shares of Common Stock for 1 share of Series O Preferred Stock. The Series O Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 19.99% of the shares of Common Stock outstanding immediately after giving effect to such conversion. ( 8 )Shares of Series X Preferred Stock acquired pursuant to the terms and conditions of a backstop commitment made by certain of the Reporting Persons in connection with the Issuer's rights offering. ( 9 )This stock option was granted on March 10, 2021 and vested on the first to occur of (i) the date that is twelve months after the date of grant, and (ii) immediately prior to the first annual meeting of the Issuer's stockholders in 2022 at which one or more members of the Issuer's Board of Directors are to be elected, subject to Matthew Perry's continued service through such date or event. ( 10 )Partners, BVF Inc. and Mr. Lampert may be deemed to have a pecuniary interest in the securities reported owned herein due to a certain agreement between Partners and Mr. Perry, who serves on the Issuer's Board of Directors and as a member of Partners, pursuant to which Mr. Perry is obligated to transfer the economic benefit, if any, received upon the sale of the shares issuable upon exercise of the securities reported owned herein to Partners. As such, Mr. Perry disclaims beneficial ownership of the securities reported herein except to the extent of his pecuniary interest therein. ( 11 )The option vested on the first to occur of (i) the date that is twelve months after the date of grant, and (ii) immediately prior to the first annual meeting of the Issuer's stockholders in 2020 at which one or more members of the Issuer's Board of Directors are to be elected, subject to Mr. Perry's continued service through such date or event. ( 12 )This stock option was granted on May 17, 2018 and vested on the first to occur of (i) the date that was twelve months after the date of grant, and (ii) immediately prior to the first annual meeting of the Issuer's stockholders in 2019 at which one or more members of the Issuer's Board of Directors are to be elected, subject to Mr. Perry's continued service through such date or event. ( 13 )This stock option was granted on February 23, 2017, and vested on the first to occur of (i) the date that was twelve months after the date of grant, (ii) the first annual meeting of the Issuer's stockholders in 2018 at which one or more members of the Issuer's Board of Directors was elected, or (iii) immediately prior to the occurrence of a Change of Control (as such term is defined in the Issuer's 2015 Equity Incentive Plan). ( 14 )The Series X1 Convertible Preferred Stock, par value $0.001 per share (the "Series X1 Preferred Stock") have no expiration date, and are convertible upon issuance; the conversion ratio is 10,000 shares of Common Stock for 1 share of Series X1 Preferred Stock. The Series X1 Preferred Stock may not be converted if, after such conversion, the Reporting Persons would beneficially own, as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended, more than 9.99% of the shares of Common Stock outstanding immediately after giving effect to such conversion. ( 15 )This stock option vests on the first to occur of (i) the date that is twelve months after the date of grant, and (ii) immediately prior to the first annual meeting of the Issuer's stockholders in 2023 at which one or more members of the Issuer's Board of Directors are to be elected, subject to the Mr. Perry's continued service through such date or event.

Remarks: For purposes of Section 16 of the Securities Exchange Act of 1934, as amended, Partners may be deemed to be a director by deputization of the Issuer due to a memberof Partners, Mr. Perry, serving on the Board of Directors of the Issuer, and his agreement to transfer the economic benefit, if any, received upon the sale ofthe shares issuable upon exercise of the securities reported owned herein to Partners.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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