Sec Form 3 Filing - Smith Stan @ MAIA Biotechnology, Inc. - 2022-07-27

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Smith Stan 2. Issuer Name and Ticker or Trading Symbol MAIA Biotechnology, Inc. [ MAIA] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 444 WEST LAKE STREET, SUITE 1700 3. Date of Earliest Transaction (MM/DD/YY) 07/27/2022 (Street) CHICAGO, IL60606 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 296,128 I See Footnote( 1 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Options $ 1.8 ( 2 ) 05/20/2030 Common Stock 25,000 I See Footno te( 1 ) Stock Options $ 1.8 ( 2 ) 11/02/2030 Common Stock 27,138 I See Footnote( 1 ) Stock Options $ 1.8 ( 3 ) 11/14/2030 Common Stock 18,000 I See Footnote( 1 ) Stock Options $ 1.8 ( 4 ) 01/28/2031 Common Stock 4,584 I See Footnote( 1 ) Stock Options $ 10 ( 5 ) 11/14/2031 Common Stock 18,000 I See Footnote( 1 ) Stock Options $ 10 ( 5 ) 11/14/2031 Common Stock 5,000 I See Footnote( 1 ) Warrants $ 6 ( 6 ) ( 6 ) Common Stock 4,517 I See Footnote( 1 ) Warrants $ 6 ( 7 ) ( 7 ) Common Stock 862 I See Footnote( 1 ) Warrants $ 6 ( 8 ) ( 8 ) Common Stock 1,288 I See Footnote( 1 ) Warrants $ 6 ( 9 ) ( 9 ) Common Stock 23,580 I See Footnote( 1 ) Warrants $ 6 ( 10 ) ( 10 ) Common Stock 2,138 I See Footnote( 1 ) Warrants $ 6 ( 11 ) ( 11 ) Common Stock 8,499 I See Footnote( 1 ) Warrants $ 6 ( 12 ) ( 12 ) Common Stock 2,120 I See Footnote( 1 ) Warrants $ 6 ( 13 ) ( 13 ) Common Stock 2,121 I See Footnote( 1 ) Warrants $ 6 ( 14 ) ( 14 ) Common Stock 2,119 I See Footnote( 1 )

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Smith Stan 444 WEST LAKE STREET, SUITE 1700 CHICAGO, IL60606 X Signatures /s/ Stan V. Smith 07/27/2022 Signature of Reporting Person Date

Explanation of Responses:

( 1 )These securities are beneficially owned by Mr. Smith through The Stan V. Smith Trust Dated 1993. ( 2 )Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options fully vested on May 20, 2021. ( 3 )Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options vested in 12 equal monthly installments beginning on December 15, 2020. ( 4 )Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options vested in 12 equal monthly installments beginning on January 29,2021. ( 5 )Represents an option to purchase shares of Common Stock granted pursuant to the 2020 Equity Incentive Plan. These options vest in 12 equal monthly installments beginning on November 15, 2021. ( 6 )Each Warrant became exercisable on the date of issuance of May 06, 2020, and expires on the earliest to occur of: (a) May, 31, 2027 or (b) immediately prior to the closing of any change of control of the issuer. ( 7 )Each Warrant became exercisable on the date of issuance of March 08, 2021, and expires on the earliest to occur of: (a) March, 7, 2028 or (b) immediately prior to the closing of any change of control of the issuer. ( 8 )Each Warrant became exercisable on the date of issuance of March 29, 2021, and expires on the earliest to occur of: (a) March 28, 2028 or (b) immediately prior to the closing of any change of control of the issuer. ( 9 )Each Warrant became exercisable on the date of issuance of April 07, 2021, and expires on the earliest to occur of: (a) April 6, 2028 or (b) immediately prior to the closing of any change of control of the issuer. ( 10 )Each Warrant became exercisable on the date of issuance of April 23, 2021, and expires on the earliest to occur of: (a) April 22, 2028 or (b) immediately prior to the closing of any change of control of the issuer. ( 11 )Each Warrant became exercisable on the date of issuance of June 1, 2021, and expires on the earliest to occur of: (a) May 31, 2028 or (b) immediately prior to the closing of any change of control of the issuer. ( 12 )Each Warrant became exercisable on the date of issuance of June 11, 2021, and expires on the earliest to occur of: (a) June10, 2028 or (b) immediately prior to the closing of any change of control of the issuer. ( 13 )Each Warrant became exercisable on the date of issuance of June 15, 2021, and expires on the earliest to occur of: (a) June 14, 2028 or (b) immediately prior to the closing of any change of control of the issuer. ( 14 )Each Warrant became exercisable on the date of issuance of June 18, 2021, and expires on the earliest to occur of: (a) June 17, 2028 or (b) immediately prior to the closing of any change of control of the issuer.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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