Sec Form 3 Filing - Pelish Henry E. @ Nuvalent, Inc. - 2024-07-09

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Pelish Henry E. 2. Issuer Name and Ticker or Trading Symbol Nuvalent, Inc. [ NUVL] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chief Scientific Officer (Last) (First) (Middle) C/O NUVALENT, INC., ONE BROADWAY, 14TH FLOOR 3. Date of Earliest Transaction (MM/DD/YY) 07/09/2024 (Street) CAMBRIDGE, MA02142 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Class A Common Stock 63,495 ( 1 ) D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares Stock Option (Right to Buy) $ 0.65 ( 2 ) 05/25/2030 Class A Common Stock 5,914 D Stock Option (Right to Buy) $ 0.87 ( 3 ) 12/15/2030 Class A Common Stock 9,627 D Stock Option (Right to Buy) $ 1.08 ( 4 ) 02/16/2031 Class A Common Stock 8,085 D Stock Option (Right to Buy) $ 6.89 ( 5 ) 04/29/2031 Class A Common Stock 3,258 D Stock Option (Right to Buy) $ 18.93 ( 6 ) 01/04/2032 Class A Common Stock 18,281 D Stock Option (Right to Buy) $ 27.85 ( 7 ) 01/06/2033 Class A Common Stock 32,452 D Stock Option (Right to Buy) $ 29.33 ( 8 ) 03/01/2033 Class A Common Stock 32,175 D Stock Option (Right to Buy) $ 72.35 ( 9 ) 01/05/2034 Class A Common Stock 28,900 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Pelish Henry E. C/O NUVALENT, INC. ONE BROADWAY, 14TH FLOOR CAMBRIDGE, MA02142 Chief Scientific Officer Signatures /s/ Nathan McConarty, attorney-in-fact 07/11/2024 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Includes 20,200 shares of Nuvalent, Inc. Class A Common Stock issuable under restricted stock units ("RSUs"). Each RSU represents the right to receive one share of Nuvalent, Inc. Class A Common Stock. The RSUs vest in three equal annual installments following January 5, 2024, subject to continued service to Nuvalent, Inc. through the applicable vesting date. ( 2 )The shares underlying this option are fully vested. ( 3 )The shares underlying this option vest as follows: 25% of the 57,759 shares originally underlying the option vested on August 3, 2021 and the remainder have vested or shall vest over the three years thereafter in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. ( 4 )The shares underlying this option vest as follows: 25% of the 27,720 shares originally underlying the option vested on February 1, 2022 and the remainder have vested or shall vest over the three years thereafter in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. ( 5 )The shares underlying this option vest as follows: 25% of the 9,198 shares originally underlying the option vested on April 29, 2022 and the remainder have vested or shall vest over the three years thereafter in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. ( 6 )The shares underlying this option vest as follows: 25% of the 35,100 shares originally underlying the option vested on January 4, 2023 and the remainder have vested or shall vest over the three years thereafter in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. ( 7 )The 42,100 shares originally underlying this option have vested or shall vest over the four years following January 6, 2023 in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. ( 8 )The 39,600 shares originally underlying this option have vested or shall vest over the four years following March 1, 2023 in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date. ( 9 )The shares underlying this option have vested or shall vest over the four years following January 5, 2024 in equal monthly installments, subject to continued service to Nuvalent, Inc. through the applicable vesting date.

Remarks: Exhibit Index: 24.1 - Power of Attorney

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