Sec Form 4 Filing - Valor IV Pharma Holdings, LLC @ Harmony Biosciences Holdings, Inc. - 2024-11-01

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Valor IV Pharma Holdings, LLC 2. Issuer Name and Ticker or Trading Symbol Harmony Biosciences Holdings, Inc. [ HRMY] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) 320 N. SANGAMON, SUITE 1200 3. Date of Earliest Transaction (MM/DD/YY) 11/01/2024 (Street) CHICAGO, IL60607 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock 11/01/2024 S 4,000,000 D $ 30.3025 7,218,033 D Common Stock 11/05/2024 S 600,000 D $ 30.3025 6,618,033 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Re porting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Valor IV Pharma Holdings, LLC 320 N. SANGAMON SUITE 1200 CHICAGO, IL60607 X Valor Management L.P. 320 N. SANGAMON SUITE 1200 CHICAGO, IL60611 X Valor Equity Capital IV LLC 320 N. SANGAMON SUITE 1200 CHICAGO, IL60611 X Valor Equity Associates IV L.P. 320 N. SANGAMON SUITE 1200 CHICAGO, IL60611 X VALOR EQUITY PARTNERS IV L.P. 320 N. SANGAMON SUITE 1200 CHICAGO, IL60611 X VALOR EQUITY PARTNERS IV-A L.P. 320 N. SANGAMON SUITE 1200 CHICAGO, IL60611 X VALOR EQUITY PARTNERS IV-B L.P. 320 N. SANGAMON SUITE 1200 CHICAGO, IL60611 X Gracias Antonio J. C/O HARMONY BIOSCIENCES HOLDINGS, INC. 630 W GERMANTOWN PIKE, SUITE 215 PLYMOUTH MEETING, PA19462 X X Sabater Juan A. 630 W. GERMANTOWN PIKE SUITE 215 PLYMOUTH MEETING, PA19462 X X Signatures Valor IV Pharma Holdings, LLC By: /s/Antonio Gracias, Sole Manager 11/05/2024 Signature of Reporting Person Date Valor Management L.P. By: /s/Antonio Gracias, CEO 11/05/2024 Signature of Reporting Person Date Valor Equity Capital IV LLC By: Valor Management L.P., its managing member By: /s/Antonio Gracias, CEO 11/05/2024 Signature of Reporting Person Date Valor Equity Associates IV L.P., By: Valor Equity Capital IV LLC, its general partner, By: Valor Management L.P., its managing member, By: /s/ Antonio Gracias, CEO 11/05/2024 Signature of Reporting Person Date Valor Equity Partners IV, L.P., By: Valor Equity Associates IV L.P., By: Valor Equity Capital IV LLC, its general partner, By: Valor Management L.P., its managing member, By: /s/ Antonio Gracias, CEO 11/05/2024 Signature of Reporting Person Date Valor Equity Partners IV-A, L.P., By: Valor Equity Associates IV L.P., By: Valor Equity Capital IV LLC, its general partner, By: Valor Management L.P., its managing member, By: /s/ Antonio Gracias, CEO 11/05/2024 Signature of Reporting Person Date Valor Equity Partners IV-B, L.P., By: Valor Equity Associates IV L.P., By: Valor Equity Capital IV LLC, its general partner, By: Valor Management L.P., its managing member, By: /s/ Antonio Gracias, CEO 11/05/2024 Signature of Reporting Person Date /s/ Antonio Gracias 11/05/2024 Signature of Reporting Person Date /s/ Juan A. Sabater 11/05/2024 Signature of Reporting Person Date

Explanation of Responses:

Remarks: Valor IV Pharma Holdings, LLC is the holder of record of the shares reported herein. Valor Funds Group LLC is the general partner of Valor Management L.P., which is the managing member of Valor Equity Capital IV LLC, which is the general partner of Valor Equity Associates IV L.P., which, in turn, is the general partner of limited partnerships (Valor Equity Partners IV L.P, Valor Equity Partners IV-A L.P. and Valor Equity Partners IV-B L.P.) that are the members of Valor IV Pharma Holdings, LLC. Antonio Gracias and Juan Sabater, each of whom is a director of the Issuer, may each be deemed to share beneficial ownership over the shares of the Issuer held by Valor IV Pharma Holdings, LLC by virtue of their positions with the above Valor entities; however, each disclaims beneficial ownership of the shares held by Valor IV Pharma Holdings, LLC

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

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