Sec Form 4 Filing - Dritschilo Anatoly @ Shuttle Pharmaceuticals Holdings, Inc. - 2023-08-14

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Dritschilo Anatoly 2. Issuer Name and Ticker or Trading Symbol Shuttle Pharmaceuticals Holdings, Inc. [ SHPH] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director X __ 10% Owner X __ Officer (give title below) _____ Other (specify below) CEO and Chairman (Last) (First) (Middle) C/O SHUTTLE PHARMACEUTICALS HOLDINGS, 401 PROFESSIONAL DRIVE, SUITE 260 3. Date of Earliest Transaction (MM/DD/YY) 08/14/2023 (Street) GAITHERSBURG, MD20879 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price COMMON STOCK 08/14/2023 G 2,100,000 ( 1 ) D $ 0 1,104,407 ( 2 ) I By Spouse COMMON STOCK 08/14/2023 G 2,100,000 A $ 0 2,100,000 ( 3 ) I By PAL Trust

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Dritschilo Anatoly C/O SHUTTLE PHARMACEUTICALS HOLDINGS 401 PROFESSIONAL DRIVE, SUITE 260 GAITHERSBURG, MD20879 X X CEO and Chairman Signatures /s/ Anatoly Dritschilo 08/18/2023 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents 2,100,000 shares held by the spouse of the Reporting Person, and over which the Reporting Person disclaims any beneficial ownership or control. Prior to the contribution, the Reporting Person's spouse held a total of 3,204,407 shares. On August 14, 2023, she contributed 2,100,000 shares to PAL Trust, a trust formed for the benefit of her adult children. ( 2 )Consists of 1,104,407 shares held by the spouse of the Reporting Person. The inclusion in this report of the 1,104,407 shares held by the Reporting Person's spouse shall in no way be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose. ( 3 )Consists of 2,100,000 shares gifted by the Reporting Person's spouse to PAL Trust, a trust formed for the benefit of the Reporting Person's adult children and for which a third party serves as external trustee and two of the Reporting Person's children serve as co-trustees. Beneficial ownership is disclaimed except to the extent the Reporting Person's spouse maintains any pecuniary interest therein. The inclusion in this report of the 2,100,000 shares held by the trust for the benefit of the Reporting Person's adult children shall in no way be deemed an admission that the Reporting Person is the beneficial owner of such securities for purposes of Section 16 or for any other purpose.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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