Sec Form 4 Filing - LEFKOFSKY ERIC P @ Tempus AI, Inc. - 2025-02-27

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person LEFKOFSKY ERIC P 2. Issuer Name and Ticker or Trading Symbol Tempus AI, Inc. [ TEM] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director X __ 10% Owner X __ Officer (give title below) _____ Other (specify below) CEO and Chairman (Last) (First) (Middle) C/O TEMPUS AI, INC., 600 WEST CHICAGO AVENUE, SUITE 510 3. Date of Earliest Transaction (MM/DD/YY) 02/27/2025 (Street) CHICAGO, IL60654 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) _____ Form filed by One Reporting Person __ X __ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Class A Common Stock 02/27/2025 J( 1 ) 3,372,045 D $ 0 1,580,928 I By Innovation Group Investors, L.P. - 2011 Series ( 2 ) Class A Common Stock 02/27/2025 S 1,580,928 D $ 58.75 0 I By Innovation Group Investors, L.P. - 2011 Series ( 2 ) Class A Common Stock 02/27/2025 J( 3 ) 132,880 D $ 0 115,751 I By Lightbank Investments 1B, LLC ( 2 ) Class A Common Stock 02/27/2025 S 115,751 D $ 58.75 0 I By Lightbank Investments 1B, LLC ( 2 ) Class A Common Stock 02/27/2025 S 145,966 D $ 58.75 0 I By Innovation Group Investors, L.P. - Series 1B ( 2 ) Class A Common Stock 02/27/2025 S 1,397,589 D $ 58.75 0 I By Lightbank Global LLC ( 2 ) Class A Common Stock 02/27/2025 G 100,000 D $ 0 26,489,477 I By Blue Media, LLC ( 2 ) Class A Common Stock 4,895,589 D Class A Common Stock 187 I By 346 Long LLC ( 2 ) Class A Common Stock 9,557,283 I By Gray Media, LLC ( 2 ) Class A Common Stock 206 I By Black Media, LLC ( 2 ) Class A Common Stock 332,131 I By Lefkofsky Family Foundation ( 2 )

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other LEFKOFSKY ERIC P C/O TEMPUS AI, INC. 600 WEST CHICAGO AVENUE, SUITE 510 CHICAGO, IL60654 X X CEO and Chairman Blue Media, LLC C/O TEMPUS AI, INC. 600 WEST CHICAGO AVENUE, SUITE 510 CHICAGO, IL60654 X Signatures /s/ Andrew Polovin, Attorney-in-Fact for Blue Media, LLC 02/27/2025 Signature of Reporting Person Date /s/ Andrew Polovin, Attorney-in-Fact for Eric P. Lefkofsky 02/27/2025 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents a pro rata distribution without additional consideration, and not a purchase or sale of securities, by Innovation Group Investors, L.P. - 2011 Series. ( 2 )The Reporting Person is (i) a member of, and controls a limited liability company that is a member of, 346 Long LLC, (ii) the sole manager of each of Black Media, LLC, Blue Media, LLC, Gray Media, LLC, Lightbank Investments 1B, LLC, Lightbank Global LLC, (iii) the manager of the general partner of Innovation Group Investors, L.P. - 2011 Series and Innovation Group Investors, L.P. - Series 1B and (iv) a trustee of Lefkofsky Family Foundation. ( 3 )Represents a pro rata distribution without additional consideration, and not a purchase or sale of securities, by Lightbank Investments 1B, LLC.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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