Sec Form 3 Filing - Griffiths Richard Ian @ Silence Therapeutics plc - 2025-01-02

FORM 3 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person Griffiths Richard Ian 2. Issuer Name and Ticker or Trading Symbol Silence Therapeutics plc [ SLN] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) _____ Director X __ 10% Owner _____ Officer (give title below) _____ Other (specify below) (Last) (First) (Middle) FLOOR 1 LIBERATION STATION, ESPLANADE 3. Date of Earliest Transaction (MM/DD/YY) 01/02/2025 (Street) ST HELIER, Y9JE2 3AS 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares American Depositary Shares ( 1 ) ( 1 ) ( 1 ) Ordinary Shares 19,221,525 I By Ora Capital Limited ( 2 ) American Depositary Shares ( 1 ) ( 1 ) ( 1 ) Ordinary Shares 1,815,522 I By Sarossa Plc ( 3 ) American Depositary Shares ( 1 ) ( 1 ) ( 1 ) Ordinary Shares 1,500,000 I By Cream Capital Limited ( 4 ) American Depositary Shares ( 1 ) ( 1 ) ( 1 ) Ordinary Shares 300,000 I By Blake Holdings Limited ( 5 ) American Depositary Shares ( 1 ) ( 1 ) ( 1 ) Ordinary Shares 360,000 I By Ora Ventures Limited ( 6 ) American Depositary Shares ( 1 ) ( 1 ) ( 1 ) Ordinary Shares 190,500 I By Pinkey's Limited ( 7 ) American Depositary Shares ( 1 ) ( 1 ) ( 1 ) Ordinary Shares 3,878,454 D

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other Griffiths Richard Ian FLOOR 1 LIBERATION STATION, ESPLANADE ST HELIER, Y9JE2 3AS X Signatures /s/ Richard Ian Griffiths 01/02/2025 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Each American Depositary Share ("ADS") is immediately convertible into three ordinary shares for no consideration and has no expiration date. ( 2 )The securities are held by Ora Capital Limited ("Ora Capital"). Mr. Griffiths is a director and the controlling shareholder of Ora Capital. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein. ( 3 )The securities are held by Sarossa Plc ("Sarossa"). Mr. Griffiths is a director and the controlling shareholder of Sarossa. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein. ( 4 )The securities are held by Cream Capital Limited ("Cream"). Mr. Griffiths is a director and the controlling shareholder of Cream. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein. ( 5 )The securities are held by Blake Holdings Limited ("Blake"). Mr. Griffiths is a director and the controlling shareholder of Blake. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein. ( 6 )The securities are held by Ora Ventures Limited ("Ora Ventures"). Mr. Griffiths is a director and the controlling shareholder of Ora Ventures. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein. ( 7 )The securities are held by Pinkey's Limited ("Pinkey's"). Mr. Griffiths is a controlling shareholder of Pinkey's. Mr. Griffiths disclaims beneficial ownership of these securities except to the extent of his proportionate pecuniary interest therein.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

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