Sec Form 4 Filing - McVey Richard M @ MARKETAXESS HOLDINGS INC - 2020-11-09

FORM 4 Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940

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1. Name and Address of Reporting Person McVey Richard M 2. Issuer Name and Ticker or Trading Symbol MARKETAXESS HOLDINGS INC [ MKTX] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable) X __ Director _____ 10% Owner X __ Officer (give title below) _____ Other (specify below) Chairman & CEO (Last) (First) (Middle) C/O MARKETAXESS HOLDINGS INC., 55 HUDSON YARDS, 15TH FLOOR 3. Date of Earliest Transaction (MM/DD/YY) 11/09/2020 (Street) NEW YORK, NY10001 4. If Amendment, Date Original Filed (MM/DD/YY) 6. Individual or Joint/Group Filing (Check Applicable Line) __ X __ Form filed by One Reporting Person _____ Form filed by More than One Reporting Person (City) (State) (Zip)

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned 1.Title of Security (Instr. 3) 2. Transaction Date (MM/DD/YY) 2A. Deemed Execution Date, if any (MM/DD/YY) 3. Transaction Code (Instr. 8) 4. Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5) 5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4) 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4) Code V Amount (A) or (D) Price Common Stock, par value $0.003 per share 10/29/2020 G( 1 ) V 50,000 D $ 0 881,283 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 1,492 D $ 534.43 ( 3 ) 879,791 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 1,461 D $ 535.6 ( 4 ) 878,330 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 300 D $ 536.39 ( 5 ) 878,030 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 985 D $ 537.38 ( 6 ) 877,045 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 968 D $ 538.64 ( 7 ) 876,077 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 1,402 D $ 539.63 ( 8 ) 874,675 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 300 D $ 540.84 ( 9 ) 874,375 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 200 D $ 542.24 ( 10 ) 874,175 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 302 D $ 543.93 ( 11 ) 873,873 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 569 D $ 545.31 ( 12 ) 873,304 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 1,048 D $ 546.36 ( 13 ) 872,256 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 1,406 D $ 547.52 ( 14 ) 870,850 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 333 D $ 548.55 ( 15 ) 870,517 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 510 D $ 549.31 ( 16 ) 870,007 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 325 D $ 550.57 ( 17 ) 869,682 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 698 D $ 551.83 ( 18 ) 868,984 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 680 D $ 552.61 ( 19 ) 868,304 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 922 D $ 554.07 ( 20 ) 867,382 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 1,435 D $ 554.98 ( 21 ) 865,947 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 469 D $ 555.71 ( 22 ) 865,478 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 568 D $ 556.95 ( 23 ) 864,910 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 606 D $ 557.97 ( 24 ) 864,304 < /span> D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 1,105 D $ 559.14 ( 25 ) 863,199 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 1,499 D $ 560.15 ( 26 ) 861,700 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 2,324 D $ 561.17 ( 27 ) 859,376 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 1,400 D $ 562.28 ( 28 ) 857,976 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 343 D $ 563.22 ( 29 ) 857,633 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 1,038 D $ 564.31 ( 30 ) 856,595 D Common Stock, par value $0.003 per share 11/09/2020 S( 2 ) 973 D $ 565.46 ( 31 ) 855,622 D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities) 1. Title of Derivative Security (Instr. 3) 2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (MM/DD/YY) 3A. Deemed Execution Date, if any (MM/DD/YY) 4. Transaction Code (Instr. 8) 5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4, and 5) 6. Date Exercisable and Expiration Date (MM/DD/YY) 7. Title and Amount of Underlying Securities (Instr. 3 and 4) 8. Price of Derivative Security (Instr. 5) 9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4) Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners Reporting Owner Name / Address Relationships Director 10% Owner Officer Other McVey Richard M C/O MARKETAXESS HOLDINGS INC. 55 HUDSON YARDS, 15TH FLOOR NEW YORK, NY10001 X Chairman & CEO Signatures /s/ Jason Edelstein, as Attorney-in-Fact for Richard M. McVey 11/12/2020 Signature of Reporting Person Date

Explanation of Responses:

( 1 )Represents a bona fide gift of shares as a contribution to a charitable trust by the reporting person. ( 2 )This transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. ( 3 )The transactions were executed in multiple trades at prices ranging from $533.96 to $534.89. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 4 )The transactions were executed in multiple trades at prices ranging from $535.13 to $535.99. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 5 )The transactions were executed in multiple trades at prices ranging from $536.14 to $536.86. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 6 )The transactions were executed in multiple trades at prices ranging from $537.19 to $537.78. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 7 )The transactions were executed in multiple trades at prices ranging from $538.23 to $538.97. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 8 )The transactions were executed in multiple trades at prices ranging from $539.26 to $540. 15. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 9 )The transactions were executed in multiple trades at prices ranging from $540.37 to $541.06. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 10 )The transactions were executed in multiple trades at prices ranging from $542.15 to $542.33. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 11 )The transactions were executed in multiple trades at prices ranging from $543.47 to $544.21. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 12 )The transactions were executed in multiple trades at prices ranging from $544.80 to $545.78. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 13 )The transactions were executed in multiple trades at prices ranging from $545.92 to $546.81. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 14 )The transactions were executed in multiple trades at prices ranging from $547.04 to $548.02. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 15 )The transactions were executed in multiple trades at prices ranging from $548.04 to $548.98. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 16 )The transactions were executed in multiple trades at prices ranging from $549.04 to $549.64. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 17 )The transactions were executed in multiple trades at prices ranging from $550.05 to $551. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 18 )The transactions were executed in multiple trades at prices ranging from $551.39 to $552.35. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 19 )The transactions were executed in multiple trades at prices ranging from $552.40 to $553.06. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 20 )The transactions were executed in multiple trades at prices ranging from $553.43 to $554.41. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 21 )The transactions were executed in multiple trades at prices ranging from $554.45 to $555.43. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 22 )The transactions were executed in multiple trades at prices ranging from $555.49 to $556.31. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 23 )The transactions were executed in multiple trades at prices ranging from $556.54 to $557.38. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 24 )The transactions were executed in multiple trades at prices ranging from $557.64 to $558.26. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 25 )The transactions were executed in multiple trades at prices ranging from $558.65 to $559.63. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 26 )The transactions were executed in multiple trades at prices ranging from $559.68 to $560.67. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 27 )The transactions were executed in multiple trades at prices ranging from $560.71 to $561.66. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 28 )The transactions were executed in multiple trades at prices ranging from $561.72 to $562.54. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 29 )The transactions were executed in multiple trades at prices ranging from $562.78 to $563.63. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 30 )The transactions were executed in multiple trades at prices ranging from $563.92 to $564.85. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer. ( 31 )The transactions were executed in multiple trades at prices ranging from $565 to $565.90. The price above reflects the weighted average sales price. Detailed information regarding the number of shares sold at each separate price will be provided upon request by the Commission staff, the Issuer or a security holder of the Issuer.

Remarks: This is the first of two Form 4s filed by Mr. McVey on November 12, 2020.

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).

** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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